Analysis of human genetic variation in candidate genes Ander positive selections on the human linage
Título de la tesis:
Analysis of human genetic variation in candidate genes Ander positive selections on the human linage
Autor/es:
Moreno Estrada, Andrés
Tipo de documento:
Tesis (Doctoral)
Universidad:
UPF
Departamento:
Ciències Experimentals i de la Salut
Idioma:
Anglès
Palabras clave:
Genètica de poblacions humanes, Genètica humana, Variació, Selecció natural, Human population genetics, Human genetics, Variation, Natural selection
Fecha de la defensa:
21-04-2009
Notas:
Tesis dirigida por: Bosch Fusté, Elena
Resumen: Natural selection has played an important role in shaping human genetic variation, thus, finding variants that have been targeted by positive selection can provide insights about which genes influence human phenotypic variability. In this work we conduct a genome-wide survey of protein-coding genes comparing humans, chimpanzees, and closely related species in order to detect the fraction of genes undergoing positive selection on the human lineage, and further investigate intraspecific variation in a subset of candidate genes in the search of recent selective events in worldwide human populatio...
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